Researchers introduced CHANGE‑seq‑BE, a genome‑wide method tailored to profile off‑target activity induced by base editors with high sensitivity. Published in Nature Biotechnology, the approach enables unbiased detection of editing events across the genome, revealing previously underappreciated off‑target signatures. The paper provides a standardized assay to quantify unintended edits from cytosine and adenine base editors, offering a route for developers to benchmark and mitigate risk. For translational teams, CHANGE‑seq‑BE supplies targetable data to refine guide RNAs and editor choice before in vivo studies.