Researchers reported an adenine base editing approach that corrects a cryptic splice mutation (IVS4+919, G>A) underlying cardiac-type Fabry disease in cells, according to a study published in Gene Therapy. The work describes how the editing strategy rescues the faulty splicing outcome at the genetic level, aiming to address the upstream cause of disease rather than downstream symptoms. The findings reinforce the feasibility of precision editing for variant types that are difficult to target with conventional genome editing tools.