Structural and mechanistic studies revealed how bacteria regulate ribonucleotide reductases (RNRs) via the transcriptional regulator NrdR, clarifying nucleotide sensing and transcriptional control of DNA precursor synthesis. Researchers reported atomic‑level insights into NrdR function and its role modulating RNR expression under varying nucleotide pools. Complementary work described in related research outlined the broader regulatory architecture managing dNTP supply and its links to bacterial growth and stress responses. Because NrdR has no eukaryotic homolog, the regulator represents a selective target for next‑generation antimicrobials. RNRs are essential enzymes that synthesize deoxyribonucleotides; targeting their bacterial regulation could yield antimicrobials that avoid cross‑reactivity with human DNA synthesis pathways.