Researchers from the Francis Crick Institute and AlveoliX reported an autologous alveolus‑on‑a‑chip built entirely from iPSC‑derived cells from a single donor. Published in Science Advances, the device simulates breathing motions and recapitulates early pathological events of Mycobacterium tuberculosis infection in an immunocompetent, genetically matched human system. Authors propose the platform for personalized disease modeling and for testing host‑directed therapies and antibiotics without interspecies differences inherent to animal models.