Artificial intelligence continues to disrupt biomedical research and diagnostics with novel algorithms and frameworks. A personalized machine learning system for wearable robotics significantly improves arm function in motor-impaired patients, offering tailored rehabilitation solutions. New AI models accurately classify myopia severity and distinguish between similar spinal infections via MRI. An innovative AI tool developed at UC San Diego drastically reduces training data requirements for medical image analysis, potentially lowering costs. However, challenges persist, as evidenced by FDA’s AI platform Elsa generating fabricated studies, raising concerns about reliance on AI without rigorous validation.