The Sam and Ann Barshop Institute for Longevity and Aging Studies at UT San Antonio secured up to $38 million from ARPA‑H to establish a multi‑year program focused on aging and healthy longevity. The funding will support translational projects aimed at interventions and biomarkers to extend resilience across the lifespan and position UTSA as a national center for aging research. ARPA‑H’s award reflects growing federal emphasis on longevity science and the agency’s willingness to fund high‑risk, high‑reward programs. The Barshop grant will enable collaborative efforts across basic, translational, and implementation research with the goal of generating actionable interventions that can be tested in human cohorts.