Researchers at the Arc Institute have pioneered a universal gene editing platform employing bridge recombinases that facilitates large-scale genomic rearrangements in human cells, including insertions, deletions, and inversions of DNA segments up to a million base pairs. This RNA-guided recombinase system overcomes the limitations of existing genome editing tools restricted to small modifications, enabling precise manipulation of entire genomic regions. The technology holds transformative potential for gene therapy and complex genomic studies, representing a leap toward more comprehensive genetic engineering capabilities.