Nature Biotechnology published complementary preclinical advances showing micelle-based delivery can both potentiate antifungal drugs and reduce host toxicity. One study engineered a host-defense peptide mimic that self-assembles into delivery micelles and demonstrated effective combinatorial antifungal therapy in animal models. A separate team developed self-assembling peptide micelles that improved drug solubility and targeting, enhancing efficacy against invasive fungi. Both reports include pharmacology data showing improved therapeutic index versus free drug and suggest a path to combination regimens for severe fungal infections. The approaches aim to address the narrow therapeutic windows and toxicity that have limited advances against systemic mycoses.