A Nature Communications study linked widespread antibiotic contamination in urban Indian sewage with accelerated selection for antimicrobial‑resistant bacteria and resistance genes. Researchers integrated chemical measurements of antibiotic residues with metagenomic profiling of sewage microbiomes and found spatial hotspots where drug concentrations correlated with higher resistance gene prevalence. The work maps environmental reservoirs that may feed clinical AMR burdens and calls for wastewater management, pharmaceutical stewardship and regulatory enforcement to curb environmental drivers of resistance.