A narrative review argues that procalcitonin and C-reactive protein can optimize antibiotic use in hospital-acquired pneumonia when interpreted through serial kinetics rather than single static thresholds. The piece focuses on how repeated measurements can better reflect treatment response and help avoid overtreatment. The review’s emphasis on kinetic monitoring aligns with broader stewardship goals—reducing unnecessary exposure while maintaining clinical safety. For hospitals, the practical lever is whether workflows can support timely serial sampling and consistent interpretation. Stewardship programs may also use the review to refine protocols for escalation, continuation, and discontinuation decisions across patient subgroups.