Johns Hopkins University researchers used advanced structural proteomic technology (LiP-MS) to identify over 200 misfolded proteins potentially contributing to age-related cognitive decline in a rat model. Their findings suggest that amyloid-beta and tau plaques are only part of a larger constellation of protein misfolding events affecting brain function. This broad set of protein abnormalities opens new avenues for therapeutic targeting in Alzheimer’s and dementia patients over age 65, according to a publication in Science Advances led by Dr. Stephen Fried.