Recent research from Baylor College of Medicine reveals that Alzheimer’s disease affects more than just the brain. Using a Drosophila model, the team showed distinct effects of amyloid β peptides and Tau protein on central and peripheral tissues, respectively. Amyloid β peptides caused neuronal death primarily in sensory neurons, linked to lactate dehydrogenase expression and stress pathways. This expands the understanding of Alzheimer’s pathology beyond the central nervous system.