DeepMind’s latest AI model, AlphaGenome, offers a pioneering approach to predicting the effects of DNA sequence variations on gene regulation. Unlike protein structure predictions by AlphaFold, this model tackles complex gene expression control mechanisms by integrating multiple molecular processes. Early adopters foresee AlphaGenome facilitating in silico experiments, expediting research on genetic variants implicated in diseases. The tool is set to be freely available for non-commercial use, promising to transform genomics and precision medicine by decoding non-coding DNA functions.