EMBL‑EBI, DeepMind, NVIDIA and collaborators released a massive expansion of AI‑predicted protein complex structures to the AlphaFold Database, providing millions of models for multi‑protein assemblies. The release extends AlphaFold’s scope beyond single‑chain predictions and offers structural hypotheses for protein‑protein interactions at scale. The dataset includes predicted interfaces and confidence metrics intended to guide experimentalists and accelerate target validation, drug design and mechanistic studies. The consortium emphasized open access to support global research efforts and downstream computational annotation. Biotech teams focused on structural biology, antibody design or small‑molecule docking should review the dataset as a hypothesis engine for target engagement and as a resource to prioritize experimental structure determination.