The NIH’s All of Us research program reached its recruitment goal of one million participants, delivering a cohort designed to reflect the diversity of the U.S. population. NIH reported the milestone as a pivotal resource for precision medicine studies and for validating genotype–phenotype associations across ancestries. The dataset’s scale and diversity are expected to accelerate discovery of risk variants, improve polygenic risk model calibration in underrepresented groups, and support translational work across industry and academia. Researchers and commercial partners will likely leverage the resource for biomarker discovery and drug-target validation.