Artificial intelligence is rapidly reshaping protein engineering and drug development. University of Copenhagen secured a $109 million grant from Novo Nordisk Foundation to establish a protein design center aimed at advancing scientific and practical applications, including targeted treatments and environmental remediation. Additionally, an AI-informed approach called AiCE integrates structural and evolutionary constraints to accelerate protein engineering without specialized training of new models. This paradigm shift enables rapid creation and evolution of proteins, poised to impact therapeutics development significantly. These innovations underscore the increasing synergy between computational tools and biological research.