Colorado State University researchers used artificial intelligence to design modified antibodies that fluoresce inside living cells, enabling real‑time visualization of intracellular protein activity. The work, reported by the university, combines AI‑guided antibody engineering with live‑cell imaging to track gene‑expression errors and other intracellular events relevant to cancer and disease biology. The method accelerates probe development and expands the toolkit for dynamic cellular assays, with potential applications in drug discovery, target validation and basic research. The team suggests the approach reduces the time and expertise barrier for creating intracellular antibody probes. Clarification: these engineered antibodies act as intracellular fluorescent reporters, allowing researchers to observe protein localization and dynamics in living cells without genetic tagging. Broad adoption will depend on probe specificity, cell delivery, and potential perturbations to endogenous biology.