Nature Biotechnology published two papers advancing computational tooling for single‑cell research: a comprehensive 'parts list' of promoters and gRNA scaffolds to improve mammalian prime editing workflows, and CellWhisperer, a multimodal AI system that answers natural‑language queries about single‑cell RNA‑seq datasets. Both studies release resources aimed at accelerating experimental design and democratizing analysis for genomics labs. Authors and editors argue the technical catalogs and chat‑style interfaces reduce barriers between bench scientists and large single‑cell datasets; they anticipate faster experimental iteration and broader adoption of single‑cell assays in translational settings.