A team from Chan Zuckerberg Biohub, led by mass spectrometry expert Josh Elias, developed a novel mass spectrometry-based method to map protein subcellular localization changes, notably during viral infection. By tagging proteins based on compartment residency and enriching organelles via immunoprecipitation, they measured protein distributions revealing relocation events linked to processes such as ferroptosis, a regulated cell death pathway. This spatial proteomics advance enables deeper mechanistic insights into protein functions within cells and disease states beyond traditional fractionation methods. The tool offers dynamic and multidimensional views of protein activities critical for understanding pathology and therapeutic targets.