Artificial intelligence continues to shape oncology by providing improved diagnostics and drug development pathways. The Radiological Society of North America’s AI Challenge showcased models that independently interpret mammograms matching expert radiologist performance. AI-enabled deep radiomics applied to PET/CT imaging has demonstrated enhanced chemotherapy response prediction in breast cancer. Additionally, innovative computational approaches combine protein structure data and machine learning to predict effective cancer drug combinations. These AI innovations offer promising improvements in personalized cancer care and precision medicine.