Cold Spring Harbor Laboratory researchers introduced BATMAN, an AI model trained on a comprehensive TCR-peptide interaction database (BATCAVE) with over 22,000 entries. This technology significantly enhances the prediction of peptide binding to T cell receptors, which is critical for designing safer and more effective TCR-based immunotherapies by minimizing off-target effects. These computational innovations mark a step forward in precision medicine focused on immune cell engineering against cancer and infectious diseases.