Researchers at Stanford and the Arc Institute have pioneered generative AI models capable of designing complete bacteriophage genomes, advancing beyond single-gene engineering to whole viral genomes with validated infectivity and antibacterial activity. The Evo series of foundation models, particularly Evo 1 and Evo 2, trained on millions of microbial genomes, produced synthetic phages that successfully replicated and lysed bacteria in experimental assays. This breakthrough lays the groundwork for AI-driven phage therapies targeting antibiotic-resistant infections.