Google DeepMind introduced AlphaGenome, an AI foundation model that simultaneously predicts diverse genomic features such as gene expression, RNA splicing, chromatin accessibility, histone modifications, transcription factor binding, and 3D genome architecture from DNA sequences. Benchmarking outcomes show state-of-the-art or better performance on nearly all tasks compared to specialized models, unifying multiple analysis workflows. This integration enhances predictive accuracy, including for variant regulatory effects, offering a powerful tool for healthcare providers and researchers investigating rare genetic variants.