Aureka launched Open Drug Discovery Engine (OpenDDE), releasing an open-source, all-atom biomolecular foundation model aimed at AI-driven therapeutic discovery and structure-based reasoning over biomolecules. The model is presented as a preview focused on biomolecular structure modeling and co-folding, with downstream capabilities—such as molecular design, affinity prediction, and experimental feedback—requiring further validation. Aureka emphasized it retains its broader wet-lab discovery loops and antibody discovery programs internally. OpenDDE is released with an Apache-2.0 license and includes implementation support such as Python 3.11+ requirements and Docker support, giving the community a reproducible artifact in a market where many AI biotech claims remain proprietary. The release signals how AI-first drug discovery companies are balancing open technical credibility with closed data and workflow advantages to maintain differentiation.