Researchers led by the University of Pennsylvania employed artificial intelligence to screen venom-derived peptides, discovering potent new antimicrobial compounds amid the pressing threat of antimicrobial resistance. Venoms from snakes, spiders, and scorpions possess rich libraries of bioactive peptides evolved over millions of years. AI-enabled mining accelerates identification of fast-acting, specific antimicrobials, with potential to combat resistant bacterial infections. This approach leverages the natural evolutionary optimization of venoms for biomedical discovery.