Researchers at Stanford University and Arc Institute unveiled the first successful generation of complete, functional bacteriophage genomes designed by artificial intelligence. Using Evo foundation models trained on millions of viral genomes, the team synthesized 302 AI-designed viral genomes to target bacteria, with 16 replicating and killing host cells. This breakthrough represents a significant advance in generative biology, offering a new pathway for phage therapy development against antibiotic-resistant infections. The AI-generated genomes included novel gene arrangements unseen in nature, demonstrating the promise of genome-scale AI design for therapeutics.