A critical issue facing clinical research is the underrepresentation of women, minorities, rural populations, and older adults in clinical trials, impacting the generalizability of drug efficacy and safety data. Researchers and pharmaceutical sponsors are increasingly leveraging artificial intelligence and integrated data platforms to improve patient recruitment and representation. These advanced technologies synthesize disparate data sources such as electronic health records, registries, and claims data, enabling more informed and inclusive trial design. This trend promises to make clinical trials more equitable and clinically relevant.