Artificial intelligence is increasingly shaping healthcare interventions, from AI-driven models predicting pulmonary hemorrhage in preterm infants to digital therapeutics reducing suicide attempt recurrence by over 50%. Concurrently, virtual reality simulations show promise in augmenting neonatal resuscitation training. However, concerns grow around unregulated AI chatbots providing mental health advice without safeguards, prompting calls for regulatory oversight. These advances highlight AI’s dual promise and challenges in transforming patient care within neonatology and mental health sectors.