Cadence Molecular Sciences, collaborating with Treeline Biosciences, has launched ROCS X, an AI-enhanced virtual screening platform that conducts ultra-fast 3D searches on trillions of synthetically accessible drug-like molecules. Leveraging physics-based shape and electrostatics overlay combined with AI models, ROCS X achieves performance increases by orders of magnitude compared to previous tools. This breakthrough accelerates the identification of novel chemical scaffolds for drug discovery projects, as reported in validations and industry collaborations.