Scientists wielding artificial intelligence have mined venom proteomes from snakes, spiders, and scorpions to uncover potent new antimicrobial peptides addressing the global crisis of antibiotic resistance. Venoms’ evolutionary refinement provides molecules tuned to breach biological defenses, offering fast-acting, specific candidates for novel antibiotics. This study, published in Nature Communications, bridges computational biology and venom chemistry, highlighting venom-derived therapeutics’ promise in reducing multi-drug resistant infections.