Researchers unveiled CLASSIC, an ultra‑high‑throughput platform that combines long- and short‑read sequencing with AI/ML to design, synthesize and screen millions of genetic circuit variants; the work, published in Nature, dramatically accelerates mapping genetic design spaces. The platform uses barcoded libraries, fluorescence readouts and sequencing to correlate sequence to function at scale. Complementing that, a separate team demonstrated early validation of AI‑designed genetic circuits in human cells, marking a first demonstration that computationally derived circuits can function in mammalian systems. Together, these advances signal that AI‑enabled design is moving from concept to practical engineering in synthetic biology, shortening iteration cycles and expanding circuit complexity.