Researchers at Stanford University and the Arc Institute have harnessed artificial intelligence to design complete, functional bacteriophage genomes, marking a breakthrough in genome engineering. Using the Evo AI model trained on millions of prokaryotic genomes, the team generated novel bacteriophage variants capable of replicating and killing bacteria, offering promising new avenues to develop phage therapies against antibiotic-resistant infections. This innovation transcends single-gene design by incorporating complex genome interactions, potentially revolutionizing targeted antibacterial treatments.