Researchers at École Polytechnique Fédérale de Lausanne released BindCraft, an automated computational pipeline enabling de novo design of functional protein binders with significantly enhanced hit rates (10-100%) compared with traditional methods (<1%). The system utilizes self-attention and multi-source data integration to generate multiple high-affinity binders from a small library, demonstrating therapeutic potential against cell-surface receptors, allergens, and nucleases like CRISPR-Cas9. BindCraft’s efficient, ‘one-shot’ design approach presents a powerful new tool for drug discovery, with the pipeline openly available under the MIT license.