Researchers from Whitehead Institute reported a genome-wide screening approach to identify producer-cell modifications that improve production and delivery potency of engineered virus-like particles (eVLPs). The study, published in Nature Communications, describes how gene edits in producer cells can increase functional payload carriage. The team ran a genome-wide search by creating a large pool of producer cells with nearly every gene switched off, then analyzing how those perturbations affected particle production. The work highlighted specific pathways that enable higher guide RNA output, which translated into more potent particles across multiple gene editing tools and delivery-vehicle designs. The platform is aimed at improving scalable and consistent manufacturing of cell-delivered gene therapies by addressing the often-overlooked biology of how producer cells assemble delivery vehicles.