RECOVER-NEURO demonstrated feasibility for a centralized hub model to deliver home-based digital and device interventions across multiple sites for long COVID cognitive symptom studies. The operational design used NYU Langone Health as a central hub for kit preparation, device programming, remote supervision, adherence monitoring, and equipment recovery, while local sites handled recruitment, consent, and standardized clinical assessments. The trial enrolled 328 participants across 22 U.S. sites and reported high intervention uptake and adherence, supporting the logistics case for centralized coordination in multisite digital trials. For biotech and trial operations teams, the model reduces implementation variability and could streamline scaling of home-delivered interventions beyond long COVID.