Innovations in artificial intelligence and imaging are revolutionizing cancer care through improved diagnostics and personalized therapies. AI integration enables enhanced tumor profiling and treatment recommendation, exemplified by Caris Life Sciences' MI Cancer Seek assay gaining broader validation and AI-powered longitudinal monitoring in oncology. Concurrently, the emergence of volumetric amide-proton transfer weighted MRI offers non-invasive differentiation of pediatric glioma grades, while novel liquid biopsy tools provide ultra-sensitive tracking of treatment responses.