Recent computational advances enable novel insights into human biology and disease. A new plain-language 'hypothesis grammar' framework predicts cell activity in tissues, bridging biology and computation for virtual experimental modeling with implications for personalized cancer therapy selection. Complementary large-scale proteomic studies reveal tissue-specific aging patterns with an inflection point around age 50. Additionally, advanced sequencing efforts in the 1000 Genomes Project combine nanopore and PacBio technologies to map genomic variation at unprecedented scale, expanding resources for functional genomics and precision medicine.