Researchers from David Baker’s laboratory have developed AI techniques to design protein binders targeting intrinsically disordered regions (IDRs) of proteins, long considered undruggable due to their flexible conformations. Published in Science, the methods utilize amino acid sequence-based models, not requiring structural input, broadening drug discovery opportunities across various diseases including cancer and diabetes. This breakthrough represents a major advancement in targeting over half the human proteome previously inaccessible to conventional therapeutics.