Artificial intelligence is advancing biotech precision medicine and drug discovery. Cold Spring Harbor Laboratory introduced BATMAN, an AI model trained on a comprehensive T cell receptor-peptide interaction database (BATCAVE), outperforming existing tools in predicting TCR cross-reactivity. Separately, a new AI model accelerates mRNA-based treatment development by forecasting protein production efficiency across cell types. These innovations promise to enhance immunotherapy specificity and mRNA drug design efficiency.