Innovative engineering of stem cell sheets with aligned cellular structures enhances protein secretion, bolstering regenerative therapies for chronic and acute conditions. Studies also report improved methods for culturing mesenchymal stem cells leading to enhanced tissue repair capabilities. Furthermore, destabilizing microtubules enhances platelet production from iPS cell-derived megakaryocytes, promising improved hematological treatments. These advancements collectively signify progress toward more effective, scalable, and precise regenerative medicine applications.