The GEN ’s “The State of CRISPR & Genome Editing” virtual summit, broadcast June 11, 2025, featured talks from leading researchers covering novel genome editing innovations. Highlights include Fyodor Urnov discussing rapid cures using CRISPR, Alexis Komor and Nicole Gaudelli sharing advancements in base editing, Neville Sanjana presenting new tools for probing the human noncoding genome with CRISPR screens, and Beth Shapiro detailing de-extinction efforts including the resurrection of the direwolf. The summit also addressed gene therapy accessibility challenges in Africa, reflecting growing global engagement. These insights underscore CRISPR's transformative potential for therapeutic development and environmental applications.