Groundbreaking research spans multiple fronts in oncology, including discovery of the glycosaminoglycan pathway protecting tumors from ferroptosis, mechanisms of FTO protein promoting hepatocellular carcinoma progression via m6A-mediated BUB1 mRNA stabilization and TGF-β signaling, and promising preclinical pancreatic cancer vaccines achieving tumor eradication. Also, Cabaletta Bio's CAR-T therapies show efficacy in autoimmune disease. These studies illuminate complex molecular pathways and innovative approaches vital for next-generation cancer treatment strategies.