Scientists at Xi’an Jiaotong-Liverpool University and Nanjing University have developed a novel nanoparticle system by coassembling PLGA, a biodegradable medical polymer, with albumin, a naturally abundant blood protein. This supraparticle exhibits ultrahigh colloidal stability and remarkable drug loading capacity, encapsulating up to 40% doxorubicin by weight—significantly surpassing existing PLGA formulations like Doxil. In vitro and in vivo studies demonstrate reduced side effects and enhanced therapeutic efficacy. The system offers scalable production potential, overcoming challenges of nanoparticle aggregation and low drug encapsulation prevalent in conventional platforms, and heralds improved safety and effectiveness in drug delivery for cancer and other diseases.