Recent studies shed light on epigenetic regulation mechanisms in persistent pulmonary hypertension of the newborn (PPHN) and male reproductive toxicity linked to PFAS exposure. Researchers employed advanced sequencing and profiling techniques to elucidate how epigenetic marks modulate Notch signaling pathways in neonatal pulmonary vasculature. Concurrently, NIH-funded research is advancing the understanding of PFAS impact on molecular pathways affecting male fertility. These findings enhance knowledge of disease pathogenesis and may guide development of targeted interventions.