A study in Cell Death Discovery reported that cells lacking adenosine deaminase 2 (ADA2) show markedly increased cell death accompanied by severe metabolic dysfunction. Authors mapped metabolic derangements and cell‑fate changes tied to ADA2 loss, implicating the enzyme in cellular homeostasis beyond its known immunomodulatory roles. The findings could help explain clinical phenotypes seen in ADA2‑deficient patients and point to metabolic pathways as potential therapeutic targets in related autoinflammatory and immunodeficiency syndromes.