A new Nature Communications report shows that acute exercise triggers rapid and widespread remodeling of the proteomic architecture in human immune cells, researchers Walzik, Joisten and Metcalfe reported. Using high-resolution proteomics, the team catalogued changes across multiple immune cell populations immediately after exertion, revealing pathways linked to metabolism, signaling, and antigen presentation. Authors propose that these molecular shifts underlie known clinical effects of exercise on immunity and inflammation. The dataset provides a resource for immunologists and clinical researchers exploring exercise as an adjuvant to vaccination, infection outcomes, and immunotherapy, and underscores the need to account for physical activity in immune‑monitoring studies.