Researchers dissected how capsular polysaccharides in Acinetobacter species modulate drug resistance and immune evasion. The paper details capsule‑dependent effects on antibiotic penetration, biofilm formation, and recognition by host immune components, illuminating pathways that make Acinetobacter baumannii a persistent threat in healthcare settings. These mechanistic insights provide actionable leads for designing therapeutics that target capsule synthesis or function to sensitize strains to antibiotics and restore immune clearance.