Researchers published a multiomics investigation of a pig kidney transplanted into a brain‑dead human subject and monitored for 61 days. The work provides an integrated atlas of physiological and immunological events driving rejection and organ dysfunction during prolonged xenograft perfusion. The pair of Nature papers detail systemic responses, donor‑organ changes and cellular drivers of rejection using genomics, transcriptomics and proteomics. The dataset serves as a reference for immunomodulatory strategies and genetic engineering approaches intended to extend xenograft survival and inform regulatory and clinical design for future human trials.