A Nature Communications team unveiled a 3D gut‑brain‑vascular tissue platform that models bidirectional interactions between enteric, vascular, and neural compartments. The system captures crosstalk mechanisms implicated in neuropathogenesis and allows perturbation experiments linking gut signals to neural outcomes. The platform integrates engineered tissues and microfluidics to replicate physiological flow and cell‑cell communication, enabling mechanistic studies of how gut‑derived factors influence brain inflammation and pathology. Authors highlighted use cases in neurodegenerative and inflammatory disease modeling. Companies and academic labs working on microbiome therapeutics, organ‑on‑chip devices, and neuroimmune targets can use the model to screen candidates and probe mechanisms prior to in vivo validation. The work may also inform translational strategies for gut‑targeted interventions in neurological disorders.