A team publishing in Nature Communications unveiled a 3D gut‑brain‑vascular platform that models bidirectional communication among gut, neural and vascular tissues. The system recapitulates signaling pathways implicated in gut‑driven neuropathogenesis and offers a controllable testbed for mechanistic studies and drug screening. The platform combines tissue engineering and microphysiological systems to simulate cross‑talk that is difficult to capture in vivo. For translational researchers, the model provides an opportunity to probe how gut‑derived signals influence neural pathology and to evaluate therapeutic interventions in a human‑relevant setting.